Shortly after their marriage in Longmeadow, Mass., on May 2, 1907, Charlotte (nee Allen) and Edwin St. John Ward set off together as missionaries with the American Board of Commissioners for Foreign Missions. For seven years on the cusp of World War I, the couple lived in the Ottoman Empire, raising a family in a succession of cities in present day Turkey and Lebanon.

Given the scope of the Wards' activities, the term "missionaries" might be somewhat misleading. A medical doctor, Edwin (b. 1880) worked in ABCFM hospitals and universities, and he eventually left the Board to focus on medicine. While in the Levant, Edwin lectured at Aintab College (Turkey) and Syrian Protestant College (Beirut) -- the latter of which became the American University in 1920. While at Aintab, he and his wife struck up a friendship with the college president, Fred D. Shepard, who gained a measure of fame when his biography, , appeared in 1920. The book, by Alice Shepard Riggs, was intended to give Sunday School students a positive role model, but since its republication in 2001, it has become a resource for those interested in exploring missionary life in the Middle East during the 20th century.

In Beirut, the Wards became acquainted with Howard Bliss, the second president of Syrian Protestant College, and the son of the college's founder, Daniel Bliss. Established in 1866, Syrian Protestant College became an important intellectual hub and center of newspapers and scientific publication, and it played a prominent role in bringing Beirut into the 19th century Arab Renaissance, al-Nahda. Most of the scholarship on Protestant missionaries in the Middle East centers on the time of Daniel Bliss, with comparatively little addressing the 20th century. The efforts of the 19th century missionaries to bridge cultural gaps between the West and the East, however, clearly affected the second generation of missionaries, of which Charlotte and Edwin were a part. At the conclusion of World War I, when the Ottoman Empire disintegrated and much of the Arab world looked to America for support in rejecting European colonialist expansion, it was Howard Bliss who suggested to Woodrow Wilson to convene a commission to plumb Arab opinion regarding the building of states in the Middle East. The King-Crane Commission determined that there should be a single Arab state comprised of Syria, Lebanon, Palestine, and Jordan, however its conclusions were completely ignored in Europe.

The Wards appear to have left the Ottoman Empire at the start of the First World War. In her final letters, Charlotte discusses the sight of British warships off the coast of Beirut becoming a common sight, and she mentions that she and Edwin were supposed to take a furlough.