Mildred Louise Boie (called Louise) and her twin sister, Maurine Boie, were born in Plainville, Minnesota on May 20, 1907. Louise attended Mankato Teachers College, then earned her B.S. degree in Education from the University of Minnesota in 1927. From 1927 to 1929, she worked in the creative department for the Harrison-Guthrie Advertising Agency in Minneapolis, and also edited a magazine for the C. & C. Publishing Company. In 1930 Louise went to England for a year, where she studied modern English literature at Newnham College, University of Cambridge, and wrote articles for the London Morning Post and the Spectator. When she returned to the United States she took a position as instructor and head of extension classes in English at the University of Minnesota until 1934, when she received her Masters degree in English from the University. Her thesis is entitled Louisa May Alcott. Also in 1934, Louise was awarded the M.P. Sears and F.Z. Gilbert Fellowship in creative work from Radcliffe College and spent the next year studying there.

From 1935 to 1937, Louise served as assistant professor of English at Smith College. She left Smith in 1937 to be associate editor of poetry for the Atlantic Monthly in Boston, under editor Ted Weeks. She remained there until 1940 when she took a position as publicity head for the American Unitarian Association and Service Committee, organizing humanitarian work in Europe and America, and serving as editor for their publication, the Christian Register. During this time Louise also edited books for Bacon Press. Sometime in the late 1930s, while living in Boston, Louise began psychoanalysis with Dr. Leslia Dalrymple.

Feeling that she needed something more stimulating and rewarding in her life, in 1943 Louise applied for overseas work with the American Red Cross and, until 1946, was stationed at various United States Army bases in France, Italy, and Egypt, where she assisted in civilian relief. She was awarded the Bronze Star by the United States Army for her service. While overseas, Louise wrote several articles and short stories about her experiences which were published in various journals, including Ladies Home Journal, Glamour, and Radcliffe Quartery. In 1946, her book of poems, Better Than Laughter was published by the University of Minnesota Press.

In 1948, Louise married Lt. Colonel William (Bill) Saunders and moved to Fort Bragg in North Carolina, where Bill was chief engineer. After a series of health problems, Bill received an honorable discharge and they moved off base into the city of Fayetteville, where he found work as an architect.

Louise was active in numerous community services in Fayetteville. She did volunteer work for the United Services Fund, the Red Cross, the Mental Health Association, and served on the board of the County Guidance Center Advisory Council. During the 1970s and 80s Louise was executive director of the Cumberland County Council on Older Adults. In 1991, when the Sophia Smith Collection received her papers, Louise was living with Maurine and Weston LaBarre at the Carol Woods Retirement Village in Chapel Hill, North Carolina.

Although both Louise and her twin, Maurine, were active career women and travelled frequently, usually living in different cities, they always remained extremely close and corresponded regularly, sometimes on a weekly basis. Maurine Boie received her Masters in Social Work from Bryn Mawr in 1934, and thereafter she alternately taught and practiced social work in New York, Pennsylvania, and North Carolina. During the late 1930s and early 40s, she was editor-in-chief of the The Family, journal of the Family Welfare Association of America in New York City, and in 1943 she wrote the New York Baby Book which was given to every new mother in the city.

In 1939, Maurine married Weston LaBarre and they eventually moved to Durham, North Carolina. There she helped start the Durham Child Guidance Clinic and was founder of the Durham School for Pregnant School Girls. In 1960, Maurine was appointed assistant professor of Psychiatric Social Work at Duke University, where Weston LaBarre also taught, and in 1971 she returned to psychiatric social work at the Duke University Medical Center.